Ad Soyad:
Aygün Ertuğrul
Ünvanı:
Prof.Dr.
Bölüm:
Psikiyatri
İletişim:
(312) 305 18 78
1995 yılında Hacettepe Üniversitesi Tıp Fakültesi’nden okul birincisi olarak mezun oldu. 1995-2000 yılları arasında Hacettepe Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalında uzmanlık eğitimini tamamladı. 2001-2002 yılları arasında Vanderbilt Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalı, Psikofarmakoloji bölümünde Klinik Psikofarmakoloji üst uzmanlık eğitimi aldı. 2002 yılında Hacettepe Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalında öğretim görevlisi olarak göreve başladı, 2006 yılında doçent oldu. 2009 yılında Hacettepe Üniversitesi Nörolojik Bilimler ve Psikiyatri Enstitüsü’nde Temel Nörolojik Bilimler doktorasını tamamladı. 2011 yılında profesör oldu. 1995’te İhsan Doğramacı Bilim Ödülü’nü, 2002’de ABD’de NARSAD (National Alliance For Research on Schizophrenia and Depression) Genç Araştırmacı Ödülü’nü, 2003’te TÜBİTAK Beyin Araştırmaları Derneği Araştırma Projesi Teşvik Ödülü’nü, 2006’da European College of Neuropsychopharmacology (ECNP) Araştırma Ödülü’nü, 2012’ de Avrupa Psikiyatri Kongresi poster birincilik ödülü’nü aldı.
1.Ertugrul, A., Ulug, B. The Influence of Neurocognitive Deficits and Symptoms on Disability in Schizophrenia. Acta Psychiatrica Scandinavica,105,196-201 (2002).
2. Ertugrul, A. Clozapine and Suicide. American Journal of Psychiatry,159, 323 (2002).
3. Ertugrul, A., Meltzer, H.Y. Antipsychotic Drugs in Bipolar Disorder. International Journal of Neuropsychopharmacology,6, 277-284 (2003).
4. Ertugrul, A., Ulug, B. Perception of Stigma Among Patients with Schizophrenia. Social Psychiatry and Psychiatric Epidemiology,39, 73-77 (2004).
5.Yazıcı, K.M., Demirci, M., Demir, B.,Ertugrul, A.Abnormal Somatosensory Evoked Potentials in Two Patients with Conversion Disorder. Psychiatry and Clinical Neurosciences,58, 222-225 (2004).
6. Sumiyoshi, T., Roy, A., Anil, E., Jayathilake, K.,Ertugrul, A.,Meltzer, H.Y. A Comparison of Incidence of Diabetes Mellitus Between Atypical Antipsychotic Drugs: A Survey for Clozapine, Risperidone, Olanzapine and Quetiapine, Journal of Psychopharmacology,24,3 (2004).
7. Ertugrul, A., Kennedy, J.L., Masellis, M., Basile, V.S., Jayathilake, K., Meltzer,H.Y. No Association of the T102C Polymorphism of the Serotonin 2A Receptor Gene with Suicidality in Schizophrenia. Schizophrenia Research,69, 301-305 (2004).
8.Kurne, A.,Ertugrul, A.,Anıl Yagcıoğlu, A.E., Yazıcı, K.M. Venous Thromboembolism And Escitalopram. General Hospital Psychiatry,26, 481– 483 (2004).
9.Anıl Yağcıoğlu, A.E, Kıvırcık Akdede, B.B., Turgut, T.I., Tümüklü, M., Yazıcı, M. K., Alptekin, K.,Ertugrul, A., Jayathilake, K., Göğüş, A., Tunca, Z., Meltzer, H.Y. A Double-Blind Controlled Study of Adjunctive Treatment with Risperidone in Schizophrenic Patients Partially Responsive to Clozapine: Efficacy and Safety Journal of Clinical Psychiatry,6, 6372 (2005).
10.Mercan, S., Uzun, M.,Ertugrul, A., Ozturk, I., Demir, B., Sulun, T. Psychopathology and Personality Features In Orthopedic Patients With Boxer’s Fractures. General Hospital Psychiatry,27,13-17 (2005).
11.Ertugrul, A.,Anıl Yagcıoğlu, A.E., Eni, N., Yazıcı, K.M.Obsessive Compulsive Symptoms In Clozapine Treated Schizophrenic Patients. Psychiatry and Clinical Neurosciences,59, 219-222 (2005).
12.Ertugrul, A., Demir, B. Clozapine Induced Tardive Dyskinesia: A Case Report, Progress in Neuropsychopharmacology & Biological Psychiatry,29, 633-635 (2005).
13. Özer, S., Arsava, M.,Ertugrul, A., Demir, B. Obsessive Compulsive Symptoms Associated With Quetiapine Treatment in a Schizophrenic Patient: A Case Report, Progress in Neuropsychopharmacology & Biological Psychiatry, 30, 724-727 (2006).
14. Ertugrul, A. ,Ucar, G. , Başar, K. , Demir, B., Yabanoglu, S., Ulug, B. The influence of clozapine on platelet serotonin, monoamine oxidase and plasma serotonin levels, Psychiatry Research, 149, 49-57 (2007).
15.Sumiyoshi, T., Park, S., Jayathilake, K., Roy, A.,Ertugrul, A., Meltzer, H.Y. ‘Effect of buspirone, a serotonin(1A) partial agonist, on cognitive function in schizophrenia: A randomized, double-blind, placebo-controlled study.’ Schizophenia Research, 95(1-3),158-168 (2007).
16.Meltzer, H.Y., Bobo, W.V., Roy, A.,Jayathilake, K., Chen,Y.,Ertugrul, A, Yagcioglu, E.A., Small, J. Comparing Clozapine and High Dose Olanzapine In Treatment-Resistant Patients With Schizophrenia. Journal of Clinical Psychiatry, 69 (2), 274-285 (2008).
17.Gürses, N.,Ertuğrul, A.,Özer, S., Ergün-Lay, E., Temuçin, Ç., Demir, B. ‘Bir konversiyon bozukluğu hastasında beyin kan akımı değişiklikleri ve uyarılmış potansiyellere ilişkin bulgular. Türk Psikiyatri Dergisi, 19 (1), 101-107 (2008).
18. Bakkaloğlu, B., Yabanoğlu, S., Özyüksel, B.R. ,Uçar, G., Ertuğrul, A., Demir, B., UluğB.Platelet and Plasma Serotonin Levels and Platelet Monoamine Oxidase Activity in Patients with Major Depression: Effects of Sertraline Treatment. Turkish Journal of Biochemistry, 33:3, 97-103 (2008).
19.Sumiyoshi, C.,Ertugrul, A.,Yagcioglu, A.E., Sumiyoshi, T. Semantic memory deficits based on category fluency performance in schizophrenia: similar impairment patterns of semantic organization across Turkish and Japanese patients.Psychiatry Research, 167(1-2):47-57 (2009).
20.Ulay, H.T.,Ertuğrul, A.Otizmde nörogörüntüleme bulguları: bir gözden geçirme. Türk Psikiyatri Dergisi 20(2):164-74 (2009).
21.Özer, S., Özcan, H., Şenses Dinç, G.,Ertuğrul, A.,Rezaki, M., Uluşahin, A. Katı İnsan Sendromunda Konversiyon Bozukluğu Yanlış Tanısı: İki Olgu. Türk Psikiyatri Dergisi 20 (4), 2009.
22.Ertugrul, A.,Volkan-Salanci, B., Basar, K., Oguz, K.K., Demir, B., Ergul-Lay, E., Sentürk, S., Cila, A., Erbas,B., Ulug,B. The effect of clozapine on regional cerebral blood flow and brain metabolite ratios in schizophrenia: relationship with treatment response. Psychiatry Research 174 (2), 121-129 (2009).
23.Ergün EL, Volkan-Salanci B,Ertugrul A, Demir B, Erbas B. Evaluation of SISCOM in routine regional cerebral blood flow alterations after clozapine, in schizophrenia. Hell J Nucl Med. 13(1), 35-9 (2010).
24.Yazici MK, Anil Yağcioğlu AE,Ertuğrul A, Eni N, Karahan S, Karaağaoğlu E, Tokgözoğlu SL. The prevalence and clinical correlates of metabolic syndrome in patients with schizophrenia: findings from a cohort in Turkey. Eur Arch Psychiatry Clin Neurosci. 261(1), 69-78 (2011).
25.Ertuğrul A, Ozdemir H, Vural A, Dalkara T, Meltzer HY, Saka E. The influence of N-desmethylclozapine and clozapine on recognition memory and BDNF expression in hippocampus. Brain Res Bull. 84(2), 144-50 (2011).
26.Ozdemir H,Ertugrul A, Basar K, Saka E. Differential effects of antipsychotics on hippocampal presynaptic protein expressions and recognition memory in a schizophrenia model in mice. Prog Neuropsychopharmacol Biol Psychiatry. 39(1), 62-8 (2012).
27.Eren Koçak E,Ertuğrul A.Psychiatric disorders and epigenetics. Turk Psikiyatri Derg. 23(2),130-40 (2012)
28.Olmez SS, Vural I, Sahin S,Ertugrul A, Capan Y. Formulation and evaluation of clozapine orally disintegrating tablets prepared by direct compression. Pharmazie. 68(2):110-6 (2013).
29.Basar K, Eren-Kocak E, Ozdemir H,Ertugrul A. Effects of acute and chronic electroconvulsive shocks on glycogen synthase kinase 3β level and phosphorylation in mice. J ECT. 29(4) 265-70 (2013).
30.Sumiyoshi C,Ertugrul A, Yağcıoğlu AE, Roy A, Jayathilake K, Milby A, Meltzer HY, Sumiyoshi T. Language-dependent performance on the letter fluency task in patients with schizophrenia. Schizophr Res. 152(2-3):421-9 (2014).
31. Ozcelik-Eroglu E, Ertugrul A, Oguz KK, Has AC, Karahan S, Yazici MK. Effect of clozapine on white matter integrity in patients with schizophrenia: a diffusion tensor imaging study. Psychiatry Res. ; 223(3):226-35 (2014).
32. Yıldız Mİ, Temuçin Ç, Ertuğrul A. Şizofreni Hastalarında Belirtilerde ve Bilişsel İşlevlerdeki Değişimin Transkraniyal Manyetik Uyarım İle Ölçülen Kortikal İnhibisyon Parametrelerindeki Değişimle İlişkisi Turk Psikiyatri Derg. 26(3):161-71
33. Ertuğrul A (2015). Eş duyabilmek. Turk Psikiyatri Dergisi, 26(4), A4
34. Ertuğrul A (2016). Okurların tercihleri En fazla okunan ve en fazla atıf alanlar. Türk Psikiyatri Dergisi, 27(4),A4
35. Mutlu E, Yazıcı MK, Barışkın E, Ertuğrul A, Gürel ŞC, Gürkan Ş, Göka E, Yağcıoğlu AEA (2019). Examination of formal thought disorder and its clinical correlates with the Turkish Version of the Thought and Language Disorder Scale (TALD-TR) in schizophrenia. Compr Psychiatry. 93:7-13
36. Anıl Yağcıoğlu AE, Ertuğrul A, Karakaşlı AA, Ağaoğlu E, Ak S, Karahan S, Yazıcı MK (2019) . A comparative study of detection of myocarditis induced by clozapine: With and without cardiac monitoring. Psychiatry Res. 279:90-97
37. Özçelik Eroğlu E, Ertuğrul A, Oğuz KK, Karahan S, Yazıcı MK.Özçelik Eroğlu E (2020). Effect of Clozapine on Proton Magnetic Resonance Spectroscopy Findings in Hippocampus. Turk Psikiyatri Derg. 31(3):159-167. doi: 10.5080/u25195.
38. Hun Şenol Ş, Gürcan G,Ertuğrul A, Karahan S, Anıl Yağcıoğlu AE (2021). Augmentation of Clozapine Due to Inadequate Treatment Response in Schizophrenia: Comparison of Patients with Augmented and Non-augmented Treatments. Turk Psikiyatri Derg. 32(1):1-7.
39. Gürcan G, Şenol ŞH, Yağcıoğlu AEA,Ertuğrul A. (2021) Clinical risk factors, phenomenology and the impact of clozapine induced obsessive compulsive symptoms. Psychiatry Res. 296:113665. doi: 10.1016/j.psychres.2020.113665.
40. Yildiz MI, Karacam Dogan M, Mutlu E, Abdullayeva L, Ozmen F,Ertugrul A (2021) All in One: Clozapine-Associated Acute Pancreatitis With Multiple Organ Involvement. J Clin Psychopharmacol. 41(2):214-216.
41. Gürcan G, Hun Şenol Ş, Anıl Yağcıoğlu AE, Karahan S,Ertuğrul A. (2021) Common Side Effects and Metabolic Syndrome due to Clozapine: Relationship with the Clinical Variables and Disability. Turk Psikiyatri Derg. 32(2):87-99.
42. Mutlu E, Abaoğlu H, Barışkın E, Gürel ŞC,Ertuğrul A, Yazıcı MK, Akı E, Yağcıoğlu AEA. (2021) The cognitive aspect of formal thought disorder and its relationship with global social functioning and the quality of life in schizophrenia. Soc Psychiatry Psychiatr Epidemiol. 56(8):1399-1410. doi: 10.1007/s00127-021-02024
43. Yazıcı MK, Özçelik Eroğlu E,Ertuğrul A, Anıl Yağcıoğlu AE, Ağaoğlu E, Karahan S, Eni N, Sağlam Aykut D, Kavak Ö, Erdem Y. (2022) Renal effects of long-term lithium therapy, revisited. Hum Psychopharmacol. 37(2):e2812. doi: 10.1002/hup.2812
44 . de Leon J, Schoretsanitis G, Smith RL, Molden E, Solismaa A, Seppälä N, Kopeček M, Švancer P, Olmos I, Ricciardi C, Iglesias-Garcia C, Iglesias-Alonso A, Spina E, Ruan CJ, Wang CY, Wang G, Tang YL, Lin SK, Lane HY, Kim YS, Kim SH, Rajkumar AP, González-Esquivel DF, Jung-Cook H, Baptista T, Rohde C, Nielsen J, Verdoux H, Quiles C, Sanz EJ, De Las Cuevas C, Cohen D, Schulte PFJ, Ertuğrul A, Anıl Yağcıoğlu AE, Chopra N, McCollum B, Shelton C, Cotes RO, Kaithi AR, Kane JM, Farooq S, Ng CH, Bilbily J, Hiemke C, López-Jaramillo C, McGrane I, Lana F, Eap CB, Arrojo-Romero M, Rădulescu FŞ, Seifritz E, Every-Palmer S, Bousman CA, Bebawi E, Bhattacharya R, Kelly DL, Otsuka Y, Lazary J, Torres R, Yecora A, Motuca M, Chan SKW, Zolezzi M, Ouanes S, De Berardis D, Grover S, Procyshyn RM, Adebayo RA, Kirilochev OO, Soloviev A, Fountoulakis KN, Wilkowska A, Cubała WJ, Ayub M, Silva A, Bonelli RM, Villagrán-Moreno JM, Crespo-Facorro B, Temmingh H, Decloedt E, Pedro MR, Takeuchi H, Tsukahara M, Gründer G, Sagud M, Celofiga A, Ignjatovic Ristic D, Ortiz BB, Elkis H, Pacheco Palha AJ, LLerena A, Fernandez-Egea E, Siskind D, Weizman A, Masmoudi R, Mohd Saffian S, Leung JG, Buckley PF, Marder SR, Citrome L, Freudenreich O, Correll CU, Müller DJ (2022). An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry 55(2):73-86. doi: 10.1055/a-1625-6388
45 . Mutlu E, Karaçam Doğan M, Ertuğrul A, Anil Yağcioğlu AE (2022). Combination With Long-Acting Injectable Antipsychotics and Utilization of Nonstandard Formulations as Compliance Enhancing Methods for Clozapine Users: A Systematic Review and A Case Series. J Clin Psychopharmacol. 2022 Feb 1. doi: 10.1097/JCP.0000000000001526
46. Okhuijsen-Pfeifer C, van der Horst MZ, Bousman CA, Lin B, van Eijk KR, Ripke S, Ayhan Y, Babaoglu MO, Bak M, Alink W, van Beek H, Beld E, Bouhuis A, Edlinger M, Erdogan IM, Ertuğrul A, Yoca G, Everall IP, Görlitz T; GROUP (Genetic Risk and Outcome of Psychosis) investigators, Grootens KP, Gutwinski S, Hallikainen T, Jeger-Land E, de Koning M, Lähteenvuo M, Legge SE, Leucht S, Morgenroth C, Müderrisoğlu A, Narang A, Pantelis C, Pardiñas AF, Oviedo-Salcedo T, Schneider-Thoma J, Schreiter S, Repo-Tiihonen E, Tuppurainen H, Veereschild M, Veerman S, de Vos M, Wagner E, Cohen D, Bogers JPAM, Walters JTR, Yağcıoğlu AEA, Tiihonen J, Hasan A, Luykx JJ (2022). Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders (2022) Transl Psychiatry. 12(1):145. doi: 10.1038/s41398-022-01884-3.
47. Ertugrul A, Anıl Yağcıoğlu AE, Ağaoğlu E, Karakaşlı A, Ak S, Yazıcı MK, de Leon J. Valproate, obesity and other causes of clozapine poor metabolism in the context of rapid titration may explain clozapine-induced myocarditis: A re-analysis of a Turkish case series (2022), Revista de psiquiatría y salud mental (Barcelona), 15(4):281-286. doi: 10.1016/j.rpsmen.2021.10.001.
48. Shelton C, Ruan CJ,Ertuğrul A, Cotes RO, De Leon J. Should we routinely add CRP to clozapine titrations? Learning from three cases. (2022) Neuropsychopharmacol Hung. 24(4):153-161.
49. Bıçakcı Ay Ş, Oğuz KK, Özçelik Eroğlu E, Has AC,Ertuğrul A. A diffusion tensor imaging study in schizophrenia patients with clozapine induced obsessive compulsive symptoms (2023). Hum Psychopharmacol 38(1):e2857. doi: 10.1002/hup.2857 50. Karaçam Doğan M, Oktar Erdoğan N,Ertuğrul A, Anil Yağcioğlu AE, Yazici MK. Hodgkin Lymphoma in Patients Receiving Clozapine Treatment: 2 Case Reports and Literature Review (2023) J Clin Psychopharmacol. 43(2):180-183. doi: 10.1097/JCP.000000000000165151. Gürcan G, Şenol ŞH, Yağcıoğlu AEA,Ertuğrul A. Effect of clozapine on suicidality in patients with schizophrenia at a university hospital in Turkey (2023). Schizophr Res S0920-9964(23)00297-9. doi: 10.1016/j.schres.2023.08.029.
52. Mutlu E, Özçelik Eroğlu E, Coşkun FÖ, Koçyiğit D, Canpolat İKN, Avcı H,Ertuğrul A, Anıl Yağcıoğlu AE A systematic chart review of pharmacological interventions in patients with clozapine-induced hypersalivation (2023). Schizophr Res S0920-9964(23)00262-1. doi: 10.1016/j.schres.2023.08.004
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Ruhsal bozukluklarda ilaç tedavileri (psikofarmakoloji), Şizofreni, Nörobilim
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Yurtdışı Deneyim / Eğitim | Klinik Psikofarmakoloji üst uzmanlık eğitimi, Vanderbilt Üniversitesi Tıp Fakültesi, Psikiyatri AD, Psikofarmakoloji Bölümü, TN, ABD (2001-2002) | |||||||||
Yabancı Dil | İngilizce |
: (312) 305 18 78
: aertugru@hacettepe.edu.tr