Hacettepe Üniversitesi Hastaneleri

Ad Soyad:

Ö. Alper Gürlek

Ünvanı:

Prof.Dr.

Bölüm:

Endokrinoloji

İletişim:

(312) 305 20 71

1989 yılında Hacettepe Üniversitesi Tıp Fakültesi’nden mezun oldu. Aynı yıl Hacettepe Tıp Fakültesi İç Hastalıkları Anabilim Dalında araştırma görevlisi olarak göreve başladı ve 1994 yılında uzman oldu. 1994-1997 yılları arasında Hacettepe Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Endokrinoloji ve Metabolizma Hastalıkları Ünitesinde fellow olarak çalıştı. Aynı dalda 1997’de yılında yardımcı doçent, 1998 yılında doçent oldu. 2001 yılında A.B.D. Mayo Klinik’te metabolik kemik hastalıkları konusunda genetik ağırlıklı araştırmalar yürüttü. Dr. Gürlek, 2004 yılında profesörlüğe atandı. 2006 yılında İngiltere Oxford Üniversitesi’nde hipofiz adenomlarının invazyon mekanizmaları konusunda klinik ve laboratuar çalışmalar yürüttü. İlgi alanları metabolik kemik hastalıkları, osteoporoz, tiroid nodülleri ve tiroiditler ile diyabet tedavisi ve komplikasyonlarıdır. Haziran 2014 itibariyle Dr. Gürlek’in uluslar arası hakemli bilimsel dergilerde yayınlanmış 63 adet yayını ve bu yayınlara yapılmış 634 atıfı bulunmaktadır.

1.	Title: Association between novel adipocytokines adiponectin, vaspin, visfatin, and thyroid: An experimental and clinical update Author(s): Cinar, N.; Gurlek, A. Source:Endocr ConnectVolume:2Issue:4Pages:R30-8Published:2013 DOI:10.1530/EC-13-0061/ Author-provided URL :	added 19-Dec-13
2.	Title: Early promising results for the endoscopic surgical treatment of Cushing's disease Author(s): Berker, M.; Işikay, I.; Berker, D.; et al. Source:Neurosurg RevPublished:2013 DOI:10.1007/s10143-013-0506-6/ Author-provided URL :	added 19-Nov-13
3.	Title: Treatment of acromegaly by endoscopic transsphenoidal surgery: surgical experience in 214 cases and cure rates according to current consensus criteria Author(s): Hazer, D. B.; Işık, S.; Berker, D.; et al. Source:J NeurosurgVolume:119Issue:6Pages:1467-77Published:2013 DOI:10.3171/2013.8.JNS13224/ Author-provided URL :	added 19-Dec-13
4.	Title:Complications of endoscopic surgery of the pituitary adenomas: analysis of 570 patients and review of the literature Author(s): Berker, Mustafa; Hazer, Derya Burcu; Yucel, Taskin; et al. Source:PituitaryVolume:15Issue:3Pages:288-300Published:SEP 2012 Times Cited:5 DOI:10.1007/s11102-011-0368-2	added 03-Sep-13
5.	Title:Pigment epithelium-derived factor increases in type 2 diabetes after treatment with metformin Author(s): Akin, Safak; Aksoy, Duygu Yazgan; Cinar, Nese; et al. Source:Clinical EndocrinologyVolume:77Issue:6Pages:852-856Published:DEC 2012 Times Cited:4 DOI:10.1111/j.1365-2265.2012.04341.x	added 03-Sep-13
6.	Title:Bilateral nephromegaly and acute renal failure in a patient with primary diffuse large B cell lymphoma of the kidneys Author(s): Serefhanoglu, S.; Bitik, B.; Aybal, A.; et al. Source:Journal of BuonVolume:16Issue:3Pages:568-569Published:JUL-SEP 2011 Times Cited:0	added 03-Sep-13
7.	Title:Serum vaspin levels in hypothyroid patients Author(s): Cinar, Nese; Gulcelik, Nese Ersoz; Aydin, Kadriye; et al. Source:European Journal of EndocrinologyVolume:165Issue:4Pages:563-569Published:OCT 2011 Times Cited:2 DOI:10.1530/EJE-11-0180	added 03-Sep-13
8.	Title:Change in amputation predictors in diabetic foot disease: effect of multidisciplinary approach Author(s): Aydin, Kadriye; Isildak, Mehlika; Karakaya, Jale; et al. Source:EndocrineVolume:38Issue:1Pages:87-92Published:AUG 2010 Times Cited:8 DOI:10.1007/s12020-010-9355-z	added 03-Sep-13
9.	Title:Circulating adiponectin represents a biomarker of the association between adiposity and bone mineral density Author(s): Agbaht, Kemal; Gurlek, Alper; Karakaya, Jale; et al. Source:EndocrineVolume:35Issue:3Pages:371-379Published:JUN 2009 Times Cited:17 DOI:10.1007/s12020-009-9158-2	added 03-Sep-13
10.	Title:Effects of bilateral ovariectomy and estrogen replacement therapy on serum leptin, sex hormone binding globulin and insulin like growth factor-I levels Author(s): Nar, Asli; Demirtas, Ezgi; Ayhan, Ali; et al. Source:Gynecological EndocrinologyVolume:25Issue:12Pages:773-778Published:2009 Times Cited:7 DOI:10.3109/09513590903159532	added 03-Sep-13
11.	Title:Evaluation of subclinical coronary atherosclerosis in mild asymptomatic primary hyperparathyroidism patients Author(s): Kepez, Alper; Harmanci, Ayla; Hazirolan, Tuncay; et al. Source:International Journal of Cardiovascular ImagingVolume:25Issue:2Pages:187-193Published:FEB 2009 Times Cited:6 DOI:10.1007/s10554-008-9369-2	added 03-Sep-13
12.	Title:Role of adipocytokines in predicting the development of diabetes and its late complications Author(s): Gulcelik, Nese Ersoz; Usman, Aydan; Gurlek, Alper Source:EndocrineVolume:36Issue:3Pages:397-403Published:DEC 2009 Times Cited:12 DOI:10.1007/s12020-009-9234-7	added 03-Sep-13
13.	Title:Serum vaspin levels in type 2 diabetic women in relation to microvascular complications Author(s): Gulcelik, Nese Ersoz; Karakaya, Jale; Gedik, Arzu; et al. Source:European Journal of EndocrinologyVolume:160Issue:1Pages:65-70Published:JAN 2009 Times Cited:31 DOI:10.1530/EJE-08-0723	added 03-Sep-13
14.	Title:Free testosterone levels and implications on clinical outcomes in elderly men Author(s): Yavuz, Burcu Balam; Ozkayar, Nihal; Halil, Meltern; et al. Source:Aging Clinical and Experimental ResearchVolume:20Issue:3Pages:201-206Published:JUN 2008 Times Cited:2	added 03-Sep-13
15.	Title:Nonsurgical cerebrospinal fluid rhinorrhea in invasive macroprolactinoma: Incidence, radiological, and clinicopathological features Author(s): Suliman, S. G. I.; Gurlek, A.; Byrne, J. V.; et al. Source:Journal of Clinical Endocrinology & MetabolismVolume:92Issue:10Pages:3829-3835Published:OCT 2007 Times Cited:19 DOI:10.1210/jc.2007-0373	added 03-Sep-13
16.	Title:Predictive ability of fasting plasma glucose for a diabetic 2-h postload glucose value in oral glucose tolerance test: spectrum effect Author(s): Karakaya, Jale; Aksoy, Duygu Yazgan; Harmanci, Ayla; et al. Source:Journal of Diabetes and Its ComplicationsVolume:21Issue:5Pages:300-305Published:SEP-OCT 2007 Times Cited:1 DOI:10.1016/j.jdiacomp.2006.05.001	added 03-Sep-13
17.	Title:Simultaneous determination of rosiglitazone and metformin in plasma by gradient liquid chromatography with UV detection Author(s): Yardimci, Ceren; Ozaltin, Nuran; Gurlek, Alper Source:TalantaVolume:72Issue:4Pages:1416-1422Published:JUN 15 2007 Times Cited:18 DOI:10.1016/j.talanta.2007.01.042	added 03-Sep-13
18.	Title:The effect of pioglitazone on angiopoietin-1, angiopoietin-2, Tie-2 and vascular endothelial growth factor in type 2 diabetes Author(s): Harmanci, Ayla; Isildak, Mehlika S.; Odevci, Metin; et al. Source:DiabetesVolume:56Pages:A598Published:JUN 2007 Times Cited:0	added 03-Sep-13
19.	Title:What are the markers of aggressiveness in prolactinomas? Changes in cell biology, extracellular matrix components, angiogenesis and genetics Author(s): Gurlek, Alper; Karavitaki, Niki; Ansorge, Olaf; et al. Source:European Journal of EndocrinologyVolume:156Issue:2Pages:143-153Published:FEB 2007 Times Cited:40 DOI:10.1530/eje.1.02339	added 03-Sep-13
20.	Title:Global assessment of the coagulation status in type 2 diabetes mellitus using rotation thromboelastography Author(s): Yurekli, Banu Pinar Sarer; Ozcebe, Osman Ilhami; Kirazli, Serafettin; et al. Source:Blood Coagulation & FibrinolysisVolume:17Issue:7Pages:545-549Published:OCT 2006 Times Cited:8	added 03-Sep-13
21.	Title:Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times Author(s): Atmaca, A.; Gurlek, A.; Dagdelen, S.; et al. Source:Experimental and Clinical Endocrinology & DiabetesVolume:114Issue:4Pages:188-191Published:APR 2006 Times Cited:7 DOI:10.1055/s-2006-924064	added 03-Sep-13
22.	Title:Thrombin-activatable fibrinolysis inhibitor activity and global fibrinolytic capacity in type 1 diabetes - Evidence for normal fibrinolytic state Author(s): Harmanci, A; Kandemir, N; Dagdelen, S; et al. Source:Journal of Diabetes and Its ComplicationsVolume:20Issue:1Pages:40-44Published:JAN-FEB 2006 Times Cited:11 DOI:10.1016/j.jdiacomp.2005.05.003	added 03-Sep-13
23.	Title:Coincidence or causality: Celiac and Crohn diseases in a case of Turner syndrome Author(s): Durusu, M; Gurlek, A; Simsek, H; et al. Source:American Journal of the Medical SciencesVolume:329Issue:4Pages:214-216Published:APR 2005 Times Cited:5 DOI:10.1097/00000441-200504000-00010	added 03-Sep-13
24.	Title:Resistance to thyroid hormone associated with autoimmune thyroid disease in a Turkish family Author(s): Aksoy, DY; Gurlek, A; Ringkananont, U; et al. Source:Journal of Endocrinological InvestigationVolume:28Issue:4Pages:379-383Published:APR 2005 Times Cited:13	added 03-Sep-13
25.	Title:A patient presenting with spinal cord compression who had two distinct follicular cell type thyroid carcinomas Author(s): Koca, E; Sokmensuer, C; Yildiz, BO; et al. Source:Journal of Endocrinological InvestigationVolume:27Issue:6Pages:562-564Published:JUN 2004 Times Cited:1	added 03-Sep-13
26.	Title:Change in the amputation profile in diabetic foot in a tertiary reference center: Efficacy of team working Author(s): Aksoy, DY; Gurlek, A; Cetinkaya, Y; et al. Source:Experimental and Clinical Endocrinology & DiabetesVolume:112Issue:9Pages:526-530Published:OCT 2004 Times Cited:17 DOI:10.1055/s-2004-821310	added 03-Sep-13
27.	Title:Isolated metastasis of malignant melanoma into follicular carcinoma of the thyroid gland Author(s): Terzi, A; Altundag, K; Saglam, A; et al. Source:Journal of Endocrinological InvestigationVolume:27Issue:10Pages:967-968Published:NOV 2004 Times Cited:5	added 03-Sep-13
28.	Title:Severe hyperglycemia associated with electroconvulsive therapy Author(s): Dagdelen, S; Akin-Atmaca, A; Gurlek, A; et al. Source:Journal of Endocrinological InvestigationVolume:27Issue:6Pages:615-616Published:JUN 2004 Times Cited:2	added 03-Sep-13
29.	Title:Symptomatic treatment of graves hyperthyroidism with lithium in states of thionamide adverse reactions - A retrospective analysis Author(s): Atmaca, A; Dogan, S; Dagdelen, S; et al. Source:EndocrinologistVolume:14Issue:6Pages:317-320Published:NOV-DEC 2004 Times Cited:0 DOI:10.1097/01.ten.0000146399.37196.12	added 03-Sep-13
30.	Title:Urinary 8-isoprostoglandin F-2 alpha: a new marker in hyperthyroidism? Author(s): Aksoy, DY; Dagdelen, S; Gurlek, A; et al. Source:Prostaglandins Leukotrienes and Essential Fatty AcidsVolume:71Issue:6Pages:411Published:DEC 2004 Times Cited:0 DOI:10.1016/j.plefa.2004.08.001	added 03-Sep-13
31.	Title:Modulation of growth factor/cytokine synthesis and signaling by 1 alpha,25-dihydroxyvitamin D-3: Implications in cell growth and differentiation Author(s): Gurlek, A; Pittelkow, MR; Kumar, R Source:Endocrine ReviewsVolume:23Issue:6Pages:763-786Published:DEC 2002 Times Cited:80 DOI:10.1210/er.2001-0044	added 03-Sep-13
32.	Title:Efficacy of ACE inhibitors and ATII receptor blockers in patients with microalbuminuria: a prospective study Author(s): Tutuncu, NB; Gurlek, A; Gedik, O Source:Acta DiabetologicaVolume:38Issue:4Pages:157-161Published:DEC 2001 Times Cited:28	added 03-Sep-13
33.	Title:Endogenous sex steroid, GH and IGF-I levels in normal elderly men: Relationships with bone mineral density and markers of bone turnover Author(s): Gurlek, A; Gedik, O Source:Journal of Endocrinological InvestigationVolume:24Issue:6Pages:408-414Published:JUN 2001 Times Cited:6	added 03-Sep-13
34.	Title:Regulation of osteoblast growth by interactions between transforming growth factor-beta and 1 alpha,25-dihydroxyvitamin D-3 Author(s): Gurlek, A; Kumar, R Source:Critical Reviews in Eukaryotic Gene ExpressionVolume:11Issue:4Pages:299-317Published:2001 Times Cited:30	added 03-Sep-13
35.	Title:The role of hepatitis C virus genotypes in development of autoimmune diseases Author(s): Sanver, A; Gurlek, A; Simsek, H; et al. Source:Diabetes CareVolume:24Issue:6Pages:1125-1126Published:JUN 2001 Times Cited:1 DOI:10.2337/diacare.24.6.1125	added 03-Sep-13
36.	Title:Efficacy of ACE inhibitors and ATII receptor blockers in insipient diabetic nephropathy Author(s): Gedik, O; Tutuncu, NB; Gurlek, A Source:DiabetologiaVolume:43Pages:A261Published:AUG 2000 Times Cited:0	added 03-Sep-13
37.	Title:Horner's syndrome: Recovery after surgical excision of intrathoracic benign multinodular goiter Author(s): Gurlek, A; Usman, A; Bayraktar, M; et al. Source:Endocrine JournalVolume:47Issue:5Pages:643-644Published:OCT 2000 Times Cited:3	added 03-Sep-13
38.	Title:Inappropriate reference range for peak bone mineral density in dual-energy X-ray absorptiometry: Implications for the interpretation of T-scores Author(s): Gurlek, A; Bayraktar, M; Ariyurek, M Source:Osteoporosis InternationalVolume:11Issue:9Pages:809-813Published:2000 Times Cited:29 DOI:10.1007/s001980070061	added 03-Sep-13
39.	Title:Increased plasma PAI-1 in relatives of type 2 diabetic patients Author(s): Gurlek, A; Bayraktar, M; Kirazli, S Source:Diabetes CareVolume:23Issue:7Pages:1036-1037Published:JUL 2000 Times Cited:0	added 03-Sep-13
40.	Title:Increased plasminogen activator inhibitor-1 activity in offspring of type 2 diabetic patients - Lack of association with plasma insulin levels Author(s): Gurlek, A; Bayraktar, M; Kirazli, S Source:Diabetes CareVolume:23Issue:1Pages:88-92Published:JAN 2000 Times Cited:25 DOI:10.2337/diacare.23.1.88	added 03-Sep-13
41.	Title:ADP and collagen sensitivity of platelets in type 2 diabetic patients improves after glycaemic control Author(s): Buyukasik, Y; Gurlek, A; Demiroglu, H Source:DiabetologiaVolume:42Pages:A322Published:AUG 1999 Times Cited:0	added 03-Sep-13
42.	Title:Analyses of cardiovascular risk factors in offsprings of type 2 diabetic patients Author(s): Gurlek, A; Bayraktar, M Source:DiabetologiaVolume:42Pages:A286Published:AUG 1999 Times Cited:0	added 03-Sep-13
43.	Title:Effect of endogenous subclinical hyperthyroidism on bone metabolism and bone mineral density in premenopausal women Author(s): Gurlek, A; Gedik, O Source:ThyroidVolume:9Issue:6Pages:539-543Published:JUN 1999 Times Cited:33 DOI:10.1089/thy.1999.9.539	added 03-Sep-13
44.	Title:Enhanced erythrocyte aggregation in type 2 diabetes with late complications Author(s): Demiroglu, H; Gurlek, A; Barista, I Source:Experimental and Clinical Endocrinology & DiabetesVolume:107Issue:1Pages:35-39Published:1999 Times Cited:10	added 03-Sep-13
45.	Title:Frequency of severe hypoglycaemia in type 1 and type 2 diabetes during conventional insulin therapy Author(s): Gurlek, A; Erbas, T; Gedik, O Source:Experimental and Clinical Endocrinology & DiabetesVolume:107Issue:3Pages:220-224Published:1999 Times Cited:20	added 03-Sep-13
46.	Title:Insulin resistance in individuals with family history of diabetes: Low HDL-cholesterol versus normal HDL cholesterol Author(s): Yildiz, BO; Gurlek, A; Bayraktar, M Source:AtherosclerosisVolume:146Pages:S35-S36Published:SEP 1999 Times Cited:0	added 03-Sep-13
47.	Title:Insulin secretion and resistance in normal tolerant offspring of type 2 diabetic patients. Author(s): Bayraktar, M; Gurlek, A; Koray, Z Source:DiabetologiaVolume:42Pages:A183Published:AUG 1999 Times Cited:0	added 03-Sep-13
48.	Title:A case of functioning insulinoma - Successful localization with dynamic spiral CT Author(s): Nar, A; Gurlek, A; Hamaloglu, E; et al. Source:Acta RadiologicaVolume:39Issue:4Pages:454-455Published:JUL 1998 Times Cited:1	added 03-Sep-13
49.	Title:Altered red blood cell rheology as a predisposing factor for diabetic nephropathy Author(s): Demiroglu, H; Gurlek, A Source:NephronVolume:79Issue:1Pages:121-122Published:MAY 1998 Times Cited:3	added 03-Sep-13
50.	Title:Amputation rate in 147 Turkish patients with diabetic foot - The Hacettepe University Hospital experience Author(s): Gurlek, A; Bayraktar, M; Savas, C; et al. Source:Experimental and Clinical Endocrinology & DiabetesVolume:106Issue:5Pages:404-409Published:1998 Times Cited:17	added 03-Sep-13

Title:Intracellular magnesium depletion relates to increased urinary magnesium loss in Type I diabetes Author(s): Gurlek, A; Bayraktar, M; Ozaltin, N Source:Hormone and Metabolic ResearchVolume:30Issue:2Pages:99-102Published:FEB 1998 Times Cited:14 DOI:10.1055/s-2007-978844

52 Title:QT dispersion and autonomic nervous system function in patients with type 1 diabetes Author(s): Aytemir, K; Aksoyek, S; Ozer, N; et al. Source:International Journal of CardiologyVolume:65Issue:1Pages:45-50Published:JUN 1 1998 Times Cited:27 DOI:10.1016/S0167-5273(98)00091-6

53Title:A miracle of salamization: Positive divided by two equals negative Author(s): Gurlek, A; Ozdemir, O Source:Diabetic MedicineVolume:14Issue:4Pages:334-335Published:APR 1997 Times Cited:1

54 Title:Analysis of diabetic ketoacidosis and hyperosmolar nonketotic coma cases Author(s): Guvener, N; Gurlek, A; Gedik, O Source:DiabetologiaVolume:40Pages:2333Published:JUN 1997 Times Cited:0

55 Title:Comparison of calcitriol treatment with etidronate-calcitriol and calcitonin-calcitriol combinations in Turkish women with postmenopausal osteoporosis: A prospective study Author(s): Gurlek, A; Bayraktar, M; Gedik, O Source:Calcified Tissue InternationalVolume:61Issue:1Pages:39-43Published:JUL 1997 Times Cited:11 DOI:10.1007/s002239900291

56 Title:Frequency of lower limb amputations in 147 Turkish patients with diabetic foot syndrome Author(s): Gurlek, A; Gedik, O; Bayraktar, M Source:DiabetologiaVolume:40Pages:1883Published:JUN 1997 Times Cited:0

57 Title:Incidence of iatrogenic hypoglycaemia in various types of insulin-treated diabetes Author(s): Gurlek, A; Gedik, O Source:DiabetologiaVolume:40Pages:1285Published:JUN 1997 Times Cited:0

58 Title:Liver tests in hyperthyroidism: Effect of antithyroid therapy Author(s): Gurlek, A; Cobankara, V; Bayraktar, M Source:Journal of Clinical GastroenterologyVolume:24Issue:3Pages:180-183Published:APR 1997 Times Cited:26 DOI:10.1097/00004836-199704000-00013

59 Title:Frequency of insulin-dependent diabetes mellitus in Turkish adult-onset diabetic population Author(s): Gurlek, A; Erbas, T; Sayinalp, S; et al. Source:Acta DiabetologicaVolume:33Issue:3Pages:216-219Published:SEP 1996 Times Cited:0

60 Title:Intracellular magnesium depletion is related to increased urinary magnesium loss in type 1 diabetes Author(s): Gurlek, A; Bayraktar, M; Ozaltin, N Source:DiabetologiaVolume:39Pages:798Published:AUG 1996 Times Cited:0

61 Title:Prevalence and risk factors for microalbuminuria in elderly patients with NIDDM. Author(s): Erbas, T; Gurlek, A; Gedik, O Source:DiabetologiaVolume:39Pages:1155Published:AUG 1996 Times Cited:0

62 Title:The effect of seasons on variceal bleeding in patients with cirrhosis Author(s): Soylu, AR; Oksuzoglu, G; Tatar, G; et al. Source:American Journal of GastroenterologyVolume:91Issue:4Pages:823-824Published:APR 1996 Times Cited:2

63 Title:DOES GONADOTROPIN-RELEASING-HORMONE ADMINISTRATION AFFECT SERUM GROWTH-HORMONE LEVELS IN POORLY CONTROLLED INSULIN-DEPENDENT AND NON-INSULIN-DEPENDENT DIABETES-MELLITUS Author(s): GURLEK, A; YORDAM, N; TELATAR, F Source:Israel Journal of Medical SciencesVolume:31Issue:11Pages:685-689Published:NOV 1995 Times Cited:0

metabolik kemik hastalıkları, osteoporoz, tiroid nodülleri ve tiroiditler ile diyabet tedavisi ve komplikasyonlarıdır

Lise

Atatürk Anadolu Lisesi

1983

Lisans

Hacettepe

Tıp Fakültesi

1989

Yüksek Öğrenim

Doktora /

Yurtdışı Deneyim / Eğitim

2001 yılında A.B.D. Mayo Klinik’te metabolik kemik hastalıkları konusunda genetik ağırlıklı araştırmalar

Yabancı Dil

İngilizce

: (312) 305 20 71

: agurlek2001@yahoo.com