Name Surname:
İncilay Lay
Title:
Prof.
Department:
Laboratories
Contact:
(312) 305 28 41
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İncilay Lay has graduated from high school of Ankara Atatürk Anadolu in 1990 and Ankara University Faculty of Medicine in 1996. She has completed her Medical Biochemistry Specialization Training in January 2001 and her Biochemistry PhD in 2004 at Hacettepe University Faculty of Medicine. She became Assistant Professor in 2005 and Associate Professor in 2011.
Between 2002-2003, she has performed researches on molecular basis of Lysosomal Storage Disorders at 'Hospital for Sick Children, Research Institute, Department of Structural Biology and Biochemistry' in Toronto, Canada with NATO Postdoctoral Scholarship by Scientific and Technical Research Council of Turkey (TUBITAK). With her works she has been awarded as a Young Investigator at 'The 22nd World Congress of Pathology and Laboratory Medicine', Korea. She has continued her researches on new therapeutic approaches in Lysosomal Storage Disorders as a visiting scientist at 'Hospital for Sick Children, Research Institute, Genetics and Genome Biology’ in Toronto, Canada with TUBITAK International Post-Doctoral Research Fellowship (2219) between 2011-2012.
Her main interest and working area is Inherited Metabolic Diseases. She is interested in molecular basis, diagnosis and prenatal diagnosis, new therapeutic strategies of Lysosomal Storage Disorders; neurodegenerative metabolic diseases; protein folding disorders; relationship between diseases and polymorphisms.
Since April 2012 she is working in Clinical Chemistry Laboratories of Hacettepe University Hospital.
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1) İncilay Sinici Lay, Aslı Pınar, Filiz Akbıyık. Classification of reasons for rejection of biological specimens based on pre-preanalytical processes to identify quality indicators at a university hospital clinical laboratory in Turkey. Clin Biochem. 2014 May 2.
2) Kilic H, Atalar E, Lay I, Yazihan N, Buyukcam F, Saygisunar U, Aksoy M, Gunduz H, Akdemir R. High-density lipoprotein subfractions and influence of endothelial lipase in a healthy Turkish population: A study in a land of low high-density lipoprotein cholesterol. Scand J Clin Lab Invest. 2014 Jan 30.
3) İncilay Sinici, Yonekawa Sayuri, Tkachyova Ilona, Gray Stevan James, Samulski RJ, Wakarchuk Warren, Mark Brian L, Mahuran Don J. In Cellulo Examination of a Beta-Alpha Hybrid Construct of Beta-Hexosaminidase A Subunits, Reported to Interact with the GM2 Activator Protein and Hydrolyze GM2 Ganglioside. PLoS One. 2013;8(3):e57908. doi: 10.1371/journal.pone.0057908.
4) S. Songül Yalçin, Emel Örün, Banu Mutlu, Yusuf Madendağ, İncilay Sinici, Arzu Dursun, H. Asuman Özkara, Zeynep Ustünyurt, Şehnaz Kutluk, Kadriye Yurdakök. Why are they having infant colic? A nested case-control study. Paediatric and Perinatal Epidemiology. 2010 Nov; 24(6):584-596.
5) Mehmet Seçer, İncilay Sinici, Aylin Heper, M. Fikret Ergüngör, Hakan Ergün. Beta-estradiol reduces lipid peroxidation and depth of injury in cold-induced brain injury model. Brain Research. 2010 Jul; 23;1345:190-196.
6) İncilay Sinici, Umut Kalyoncu, Sevilay Karahan, Sedat Kiraz, Enver Atalar. Endothelial Nitric Oxide Gene Polymorphism and Risk of Systemic Sclerosis: Predisposition effect of T-786C promoter and protective effect of 27 bp repeats in Intron 4. Clinical and Experimental Rheumatology. 2010. Mar-Apr; 28(2):169-175.
7) İncilay Sinici, Enver Atalar, Alper Kepez, Mutlu Hayran, Serdar Aksöyek, Lale Tokgözoğlu, Ferhan Özmen. Intron 4 VNTR polymorphism of eNOS gene is protective for Cardiac Syndrome X. Journal of Investigative Medicine. 2010. Jan; 58(1):23-27.
8) İncilay Sinici, E. Oğuz Güven, Egecan Şerefoğlu, Mutlu Hayran, T-786C polymorphism in promoter of eNOS gene as genetic risk factor in patients with erectile dysfunction in Turkish population. Urology. 2010. Apr; 75(4):955-960.
9) İncilay Sinici, Sevilay Karahan, Enver Atalar. Distribution of endothelial nitric oxide synthase gene polymorphisms in Turkish population. Journal of Investigative Medicine. 2009. Oct; 57(7):769-776.
10) İncilay Sinici, Michael B. Tropak, H. Asuman Özkara, Don J. Mahuran. Inhibition of endoplasmic reticulum associated degradation of mutant pro-β subunits of β-hexosaminidase by kifunensine and lactacystin. Turkish Journal of Biochemistry. 2009. Sep; 34(3):160-166.
11) *Müge Yemişci, *İncilay Sinici, *Equally contributed to the study, H.Asuman Özkara, Mutlu Hayran, Hakan Ay, Başak Çeltikci, Evren Önder, Gülseren Büyükşerbetci, E.Barış Kaya, Lale Tokgözoğlu, Turgay Dalkara. Protective role of 27 bp repeat polymorphism in intron 4 of eNOS gene in Lacunar Infarction. Free Radical Research. 2009. Mar; 43(3):272-279.
12) Evren Önder, İncilay Sinici, F. Müjgan Sönmez, Meral Topçu, H. Asuman Özkara1. Identification of two novel Arylsulfatase A mutations with a polymorphism as a cause of Metachromatic Leukodystrophy. Neurological Research. 2009. Feb; 31(1):60-66
13) Suay Özmen, Ömer Taşkın Yücel, İncilay Sinici, Ömer Afşin Özmen, Ahmet Emre Süslü, Oğuz Öğretmenoğlu, Metin Önerci. Nasal pepsin assay and pH monitoring in chronic rhinosinusitis.The Laryngoscope. 2008. May; 118(5):890-894.
14) İncilay Sinici, Evren Önder, Meral Topçu, H. Asuman Özkara. Identification of 7th hexosaminidase A mutation of Tay-Sachs disease in Turkish population. The Turkish Journal of Pediatrics. 2007. Volume:49:337-338.
15) İncilay Sinici, Maryam Zarghooni, Michael Tropak, Don Mahuran, H. Asuman Özkara. Comparison of HCMV IE and EF-1 Promoters for the Stable Expression of beta-Subunit of Hexosaminidase in CHO Cell Lines. Biochemical Genetics. 2006. 44(3-4):168-175.
16) İncilay Sinici, Michael Tropak, Don Mahuran, H. Asuman Özkara. Assessing the severity of the small in frame deletion mutation in the a-subunit of b-hexosaminidase A found in the Turkish population by reproducing it in the more stable b-subunit. Journal of Inherited Metabolic Disease.2004. 27(6):747-756.
17) İncilay Sinici, H. Asuman Özkara, Meral Topçu, Gönenç Ciliv. Biochemical and molecular characterization of mutant Hexosaminidase A in a Turkish family. Pediatrics International. 2003. 45(1):16-52.
18) Aylin Yıldırır, Funda Aybar, Lale Toközoğlu, Hakan Yaralı, Giray Kabakçı, Orhan Bükülmez, İncilay Sinici, Ali Oto. Effetcs of hormone replacement therapy on plasma homocystein and C-reactive protein levels. Gynecologic and Obstetric Investigation. 2002. 53(1):54-58.
19) Aylin Yıldırır, Lale Tokgözoğlu, İbrahim Haznedaroğlu, İncilay Sinici, Giray Kabakçı, Kenan Övünç, Serdar Aksöyek, Ali Oto, Ferhan Özman, Şerafettin Kirazlı, Sırrı Kes. Extend coronary atherosclerosis and homocystein effect endotelium marker. Angiology. 2001. 52(9):589-596.
Her main interest and working area is Inherited Metabolic Diseases. She is interested in molecular basis, diagnosis and prenatal diagnosis, new therapeutic strategies of Lysosomal Storage Disorders; neurodegenerative metabolic diseases; protein folding disorders; relationship between diseases and polymorphisms. Since April 2012 she is working in Clinical Chemistry Laboratories of Hacettepe University Hospital.
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| Foreign Experience / Education | Between 2002-2003, she has performed researches on molecular basis of Lysosomal Storage Disorders at 'Hospital for Sick Children, Research Institute, Department of Structural Biology and Biochemistry' in Toronto, Canada with NATO Postdoctoral Scholarship by Scientific and Technical Research Council of Turkey (TUBITAK). She has continued her researches on new therapeutic approaches in Lysosomal Storage Disorders as a visiting scientist at 'Hospital for Sick Children, Research Institute, Genetics and Genome Biology’ in Toronto, Canada with TUBITAK International Post-Doctoral Research Fellowship (2219) between 2011-2012. | ||||||
| Foreign Language | English |
: (312) 305 28 41
: isinici@hacettepe.edu.tr, lincilay@gmail.com