Name Surname:
Serap Sivri
Title:
Prof.
Department:
Metabolism
Contact:
(312) 305 11 41
Date of birth: 31 jan 1968
Married and has a daughter
Graduated in Ankara University Faculty of Medicine.
Residency and Subspeciality training in Hacettepe University Faculty of Medicine Department of Pediatrics, Section of Metabolism at Children’s Hospital
Her major interest is in the diagnosis and treatment of inherited metabolic disorders mainly phenylketonuria, organic acidaemias, and lysosomal storage diseases. She is responsible for treatment of inherited metabolic disorders both inpatient and outpatient clinic.
She had been worked at The John F. Kennedy Insititute for a year period and had been participated some projects there where is one of most well-known center in the metabolic field.
She had been following many national and international projects and researches on both nutrition and metabolism. She is an expertise in inborn errors of metabolism and their treatment and author of more than 30 papers on peer review international journals.
Some of her publications:
1. Yılmaz E, Cali F, Romano V, Özalp İ, Coşkun T, Tokatlı A, Kalkanoğlu H.S., Özgüç M. Molecular Basis of Mild Hyperphenylalaninaemia in Turkey. J Inherit Metab Dis 2000; 23: 523-525.
2. Romstad A, Kalkanoğlu HS, Coşkun T, Demirkol M, Tokatlı A, Dursun A, Baykal T, Özalp İ, Guldberg P, Güttler F. Molecular analysis of 16 Turkish families with DHPR deficiency using denaturing gradient gel electrophoresis (DGGE). Hum Genet 2000; 107: 546-553.
3. Kalkanoğlu HS, Coşkun T, Aydoğdu SD, Tokatlı A, Gürgey A. Factor V Leiden mutation in Turkish patients with homozygous cystationine b-synthase deficieny. J Inherit Metab Dis 2001; 24: 367-369.
4. Dursun A, Kalkanoğlu HS, Coşkun T, Tokatlı A, Bittner R, Koçak N, Yüce A, Özalp İ, Boehme HJ. Mutation analysis in Turkish patients with hereditary fructose intolerance. J Inherit Metab Dis 2001; 24: 523-526.
5. Dayangaç D, Kalkanoğlu HS, Durmuş-Aydoğdu S, Erdem H, Beşbaş N, Coşkun T. Molecular genetic analyses of cystinuria type 1 in 24 Turkish patients. Turk J Pediatr 2001; 43: 110-113.
6. Özalp İ, Coşkun T, Tokatlı A, Kalkanoğlu HS, Dursun A, Tokol S, Köksal G, Özgüç M, Köse R. Newborn PKU screening in Turkey: at present and organization for future. Turk J Pediatr 2001; 43: 97-101.
7. Kalkanoğlu HS, Romstad A, Coşkun T, Güttler F. Evaluation of a fetus at risk for dihydopteridine reductase deficiency by direct mutation analysis using denaturing gradient gel electrophoresis. Prenat Diagn 2001; 21: 868-870.
8. Dursun A, Henneke M, Özgül K, Gartner J, Coşkun T, Tokatlı A, Kalkanoğlu HS, Demirkol M, Özalp İ, Wendel U. Maple Syrup Urine Disease: mutation analysis in Turkish patients. J Inherit Metab Dis 2002; 25: 89-97.
9. Gao H, Kobayashi K, Tabata A, Tsuge H, Iijima M, Yasuda T, Kalkanoğlu HS, et al. Identification of 16 novel mutations in the argininosuccinate synthetase gene and genotype-phenotype correlation in 38 classical citrullinemia patients. Hum Mutat 2003; 22: 24-34.
10. Sozen MM, Whittall R, Oner C, Tokatli A, Kalkanoglu HS, Dursun A, Coskun T, Oner R, Humphries SE. The molecular basis of familial hypercholesterolaemia in Turkish patients. Atherosclerosis 2005; 180(1): 63-71.
11. Gunes B, Yalçın SS, Kalkanoğlu HS, Önol S, Dursun A, Coşkun T. The effect of oral L-carnitene supplementation on the lipid profiles of hyperlipidaemic children. Acta Paediatrica 2005; 94: 711-716.
12. Olcay L, Erdemli E, Kesimer M, Buyukasik Y, Okur H, Kalkanoğlu HS, Coşkun T, Altay Ç. High cystine in platelets from patients with nephropathic cystinosis: a chemical, ultrastructural, and functional evaluation. J Clin Pathol 2005; 58(9): 939-45.
13. Kalkanoglu HS, Ahring KK, Sertkaya D, Moller LB, Romstad A, Mikkelsen I, Guldberg P, Lou HC, Guttler F. Behavioural effects of phenylalanine-free amino acid tablet supplementation in intellectually disabled adults with untreated phenylketonuria. Acta Paediatr 2005; 94 (9): 1218-1222.
14. Kölker S, Garbade SF, Greenberg CR, Leonard JV, Saudubray JM, Ribes A, Kalkanoglu HS, Lund AM, Merinero B, Wajner M, Troncoso M, Williams M, Walter JH, Campistol J, Marti-Herrero M, Caswill M, Burlina AB, Lagler F, Maier EM, Schwahn B, Tokatlı A, Dursun A, Coskun T, Chalmers RA, Koeller DM, Zschocke J, Christensen E, Burgard P, Hoffmann GF. Natural history, outcome, and treatment efficacy in children and adults in glutaryl-CoA dehydrogenase deficiency. Pediatr Res 2006; 59 (6): 840-847.
15. Tavil B, Sivri HS, Coşkun T, Gurgey A, Ozyurek E, Dursun A, Tokatlı A, Altay C, Gumruk F. Hematological findings in children with inborn errors of metabolism. J Metab Dis 2006; 29 (5): 607-611.
16. Genc GA, Sivri-Kalkanoglu HS, Dursun A, Aydin HI, Tokatli A, Sennaroglu L, Belgin E, Wolf B, Coskun T. Audiologic findings in children with biotinidase deficiency in Turkey. Int J Pediatr Otolaryngol 2007; 71 (2): 333-339.
17. Sivri Kalkanoglu HS, Genc GA, Aydin HI, Tokatli A, Dursun A, Sennaroglu L, Coskun T, Belgin E, Wolf B. Genotype- phenotype correlation in patients with biotinidase deficiency. J Pediatr 2007; 150 (4): 439-442.
18. Gokmen Ozel H, Kucukkasap T, Koksal G, Kalkanoglu Sivri HS, Dursun A, Tokatli A, Coskun T. Does maternal knowledge impact blood phenylalanine concentration in Turkish children with phenylketonuria? J Inherit Metab Dis 2008;
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| Foreign Experience / Education | 1999-2000- The John F. Kennedy Institute, Copenhagen, Denmark | |||||||||
| Foreign Language | English |
: (312) 305 11 41
: ssivri@hacettepe.edu.tr